Disassociating instructive from permissive roles of brain circuits with reversible neural activity manipulations. Daniel QuintanaHayley A. BoundsJennifer BrownMay WangNikhil BhatlaJ. Simon WiegertHillel Adesnik doi:

Probing inter-areal computations with a cellular resolution two-photon holographic mesoscope. Lamiae AbdeladimHyeyoung ShinUday K. JagadisanMora B. OgandoHillel Adesnik

The logic of recurrent circuits in the primary visual cortexIan Antón Oldenburg,William D. HendricksGregory HandyKiarash ShamardaniHayleyA. Bounds,Brent Doiron, Hillel Adesnik doi:

Rapid learning of neural circuitry from holographic ensemble stimulation enabled  by model-based compressed sensing Marcus A. Triplett, Marta Gajowa, Benjamin Antin Masato Sadahiro Hillel Adesnik, Liam Paninski

Modeling the Diverse Effects of Divisive Normalization on Noise Correlations Oren WeissHayley A. BoundsHillel AdesnikRuben Coen-Cagli.  

Multifunctional Cre-dependent transgenic mice for high-precision all-optical interrogation of neural circuits Hayley A. BoundsMasato SadahiroWilliam D. HendricksMarta GajowaIan Antón OldenburgKarthika GopakumarDaniel QuintanaBosiljka TasicTanya L. DaigleHongkui ZengHillel Adesnik

Antagonistic inhibitory subnetworks control cooperation and competition across cortical space Daniel P. MossingJulia VeitAgostina PalmigianoKenneth D. MillerHillel Adesnik 

Structure and variability of optogenetic responses identify the operating regime of cortex Agostina PalmigianoFrancesco FumarolaDaniel  P. MossingNataliya KraynyukovaHillel AdesnikKenneth D. Miller


Published papers

Cortical VIP neurons locally control the gain but globally control the coherence of gamma band rhythms Julia VeitGregory HandyDaniel P. MossingBrent DoironHillel Adesnik Neuron2023 Feb 1;111(3):405-417.e5.doi: 10.1016/j.neuron.2022.10.036. Epub 2022 Nov 15.PMID: 36384143 PMCID: PMC9898108 (available on )

Yi XueLaura WallerHillel AdesnikNicolas Pégard Elife. 2022 Feb 14;11:e73266. doi: 10.7554/eLife.73266. PMID: 35156923 Free PMC article.

Savitha SridharanMarta GajowaMora B. OgandoUday JagadisanLamiae AbdeladimMasato SadahiroHayley BoundsWilliam D. HendricksIan TaylerKarthika GopakumarIan Antón OldenburgStephen G. BrohawnHillel Adesnik Neuron. 2022 Jan 27:S0896-6273(22)00008-3. doi: 10.1016/j.neuron.2022.01.008. Online ahead of print. PMID: 35120626 Free article.

Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs Kyle TuckerSavitha SridharanHillel AdesnikStephen G. Brohawn Nat Commun.2022 Aug 17;13(1):4842. doi: 10.1038/s41467-022-32441-7.PMID: 35977941 PMCID: PMC9385719DOI: 10.1038/s41467-022-32441-7

Evan H. LyallDaniel P. MossingScott R. PlutaAmir DudaiHillel Adesnik Elife. 2021 Nov 1;10:e62687. doi: 10.7554/eLife.62687.

Probing neural codes with two-photon holographic optogenetics. Adesnik H, Abdeladim L.Nat Neurosci. 2021 Oct;24(10):1356-1366. doi: 10.1038/s41593-021-00902-9. Epub 2021 Aug 16. PMID: 34400843 Review.

integration during active tactile sensation drives orientation perception. Brown J, Oldenburg IA, Telian GI, Griffin S, Voges M, Jain V, Adesnik H. Neuron. 2021 Mar 30:S0896-6273(21)00190-2. doi: 10.1016/j.neuron.2021.03.020.

Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane. Sorum B, Rietmeijer RA, Gopakumar K, Adesnik H, Brohawn SG.Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2006980118. doi: 10.1073/pnas.2006980118.

Precision multidimensional neural population code recovered from single intracellular recordings. Johnson JK, Geng S, Hoffman MW, Adesnik H, Wessel R.Sci Rep. 2020 Sep 29;10(1):15997. doi: 10.1038/s41598-020-72936-1.

Cell Type-Specific Optogenetic Dissection of Brain Rhythms.Adesnik H.Trends Neurosci. 2018 Mar;41(3):122-124. doi: 10.1016/j.tins.2018.01.001.PMID: 29499773 Review.

Complementary networks of cortical somatostatin interneurons enforce layer specific control. Naka A, Veit J, Shababo B, Chance RK, Risso D, Stafford D, Snyder B, Egladyous A, Chu D, Sridharan S, Mossing DP, Paninski L, Ngai J, Adesnik H. Elife. 2019 Mar 18;8. pii: e43696. doi: 10.7554/eLife.43696.

Superficial Layers Suppress the Deep Layers to Fine-tune Cortical Coding. Pluta SR, Telian GI, Naka A, Adesnik H.J Neurosci. 2019 Mar 13;39(11):2052-2064. doi: 10.1523/JNEUROSCI.1459-18.2018. Epub 2019 Jan 16.

Cracking the Function of Layers in the Sensory Cortex. Adesnik H, Naka A Neuron. 2018 Dec 5;100(5):1028-1043. doi: 10.1016/j.neuron.2018.10.032. Review.

Precise multimodal optical control of neural ensemble activity. Mardinly AR, Oldenburg IA, Pégard NC, Sridharan S, Lyall EH, Chesnov K, Brohawn SG, Waller L, Adesnik H. Nat Neurosci. 2018 Jun;21(6):881-893. doi: 10.1038/s41593-018-0139-8

A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex. Hakim RH, Shamardani K, Adesnik H. eLife. 2018 Feb 26;7. doi: 10.7554/eLife.28569.

Layer-specific excitation/inhibition balances during neuronal synchronization in the visual cortex. Adesnik H. J Physiology 2018 Jan 5. doi: 10.1113/JP274986.

Three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT). Pegard NC, Mardinly AR, Oldenburg IA, Sridharan S, Walller L, Adesnik H. Nature communications 2017 Oct 31;8(1):1228.

Synaptic Mechanisms of Feature Coding in the Visual Cortex of Awake Mice. Adesnik H. Neuron 2017 Aug 30;95(5):1147-1159

Cortical gamma band synchronization through somatostatin interneurons. Veit J, Hakim R, Jadi MP, Sejnowski TJ, Adesnik H Nature Neuroscience 2017 May 8. Jul;20(7):951-959.

Surround Integration Organizes a Spatial Map during Active Sensation. Pluta SR, Lyall EH, Telian GI, Ryapolova-Webb E, Adesnik H Neuron 2017 Jun 21;94(6):1220-1233.e5

Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons. Mardinly AR, Spiegel I, Patrizi A, Centofante E, Bazinet JE, Tzeng CP, Mandel-Brehm C, Harmin DA, Adesnik H, Fagiolini M, Greenberg ME. Nature. 2016 Mar 17;531(7594):371-5

Compressive light-field microscopy for 3D neural activity recording Pégard NC, Liu HY, Antipa N, Gerlock M, Adesnik H, Waller L. Optica 2016 3 (5), 517-52

Bayesian methods for event analysis of intracellular currents. Josh Merel*, Ben Shababo*, Alex Naka, Hillel Adesnik, Liam Paninski. Journal of Neuroscience Methods 269, 201610.1016/j.jneumeth.2016.05.015

Inhibitory Circuits in Cortical Layer 5. Naka A, Adesnik H. Front Neural Circuits. 2016 May 6;10:35. doi: 10.3389/fncir.2016.0003

A direct translaminar inhibitory circuit tunes cortical output. Pluta S, Naka A, Veit J, Telian G, Hakim R, Taylor D, Yao L, Adesnik H. Nature Neuroscience. 2015 2015 Nov;18(11):1631-40

A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic Inhibition. Lin WC, Tsai MC, Davenport C, Smith C, Veit J, Wilson N, Adesnik H, Kramer RH. Neuron, 2015 Dec 2;88(5):879-91.

Optogenetic pharmacology for control of native neuronal signaling proteins. Kramer RH, Mourot A, Adesnik H. Nature Neuroscience 2013 Jul;16(7):816-23.

A neural circuit for spatial summation in visual cortex. Adesnik H, Bruns W, Taniguchi H, Huang ZJ, Scanziani M. Nature. 2012 Oct 11;490(7419):226-31.

Gain control by layer six in cortical circuits of vision. Olsen SR, Bortone DS, Adesnik H, Scanziani M. Nature. 2012 Feb 22;483(7387):47-52

Lateral competition for cortical space by layer-specific horizontal circuits. Adesnik H, Scanziani M. Nature. 2010 Apr 22;464(7292):1155-60.

NMDA receptors inhibit synapse unsilencing during brain development. Adesnik H, Li G, During MJ, Pleasure SJ, Nicoll RA. PNAS. 2008 Apr 8;105(14):5597-602.

Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M. Science. 2006 Sep 22;313(5794):1792-5.

Photoinactivation of native AMPA receptors reveals their real-time trafficking. Adesnik H, Nicoll RA, England PM. Neuron. 2005 Dec 22;48(6):977-85.

Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Tomita S, Adesnik H, Sekiguchi M, Zhang W, Wada K, Howe JR, Nicoll RA, Bredt DS. Nature. 2005 Jun 23;435(7045):1052-8. Epub 2005 Apr 27.